Review Article
Antibody-Mediated Therapy against HIV/AIDS: Where Are We Standing Now?
Table 1
Anti-HIV broad neutralizing antibodies (bnAbs) in the past 10 years.
| Viral epitope | Name | Year | Sample source | References |
| V1V2 glycan site | PG9, PG16 | 2009 | Clade A-infected African | [27] | CH01 | 2011 | Chronically infected donor (CH0219) | [28] | PGT145 | 2011 | Chronically infected donor 84 | [29] | PGDM1400 | 2014 | Chronically infected donor 84 | [30] |
| V3 glycan site | PGT121, PGT125, PGT135 | 2011 | HIV-1 infected donor (at least 3 years) | [29] | 10-1074 | 2011 | Clade A-infected African donor (patient 10) | [31] |
| gp41 MPER | 2F5 | 2009 | PBMCs from patient SC44 | [32] | 4E10 | 2009 | PBMCs from patient SC44 | [32] | HK20 | 2010 | Patients plasma that showed >80% neutralization | [33] | M66.6 | 2011 | PBMCs from patient SC44 | [32] | CAP206-CH12 | 2011 | Subtype C HIV-1-infected South African donor CAP206 | [34] | 10E8 | 2012 | HIV-1-infected patient N152 | [35] | m43 | 2012 | Phage-display | [36] |
| CD4 binding site | VRC01 | 2010 | PBMCs from donor 45 | [37] | HJ16 | 2010 | Patients plasma that showed >80% neutralization | [33] | HGN194 | 2010 | Patients plasma that showed >80% neutralization | [33] | 3BNC117 | 2011 | RU01 B-cell clones from patient donor | [38] | 3BNC55 | 2011 | RU01 B-cell clones from patient donor | [38] | VRC-PG04 | 2011 | Clade A1/D infected donor | [39] | VRC-CH31 | 2011 | Chronically infected donor (CH0219) | [28] | NIH45 | 2011 | RU12 B-cell clones from patient donor | [38] | 8ANC195 | 2011 | RU12 B-cell clones from patient donor | [38] | 8ANC131 | 2011 | HIV-1 infected donor RU8 | [38] | 12A12 | 2011 | RU16 B-cell clones from patient donor | [38] | 1B2530 | 2011 | HIV-1 infected donor RU1 | [38] | 3BC176 | 2012 | HIV-1 infected patient 3B | [40] | 3BC315 | 2012 | HIV-1 infected patient 3B | [40] | CH103 | 2013 | HIV-1 infected donor CH505 | [41] | N6 | 2016 | HIV-1-infected patient Z258 | [42] |
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