Review Article

Antibody-Mediated Therapy against HIV/AIDS: Where Are We Standing Now?

Table 2

Therapeutic antibodies that are being evaluated in the clinical trials.

SourceTargetName Clinical trialReferences

ViralEnv CD4 binding site3BNC117Phase 2a[43]
Env V3 glycan site10-1074Phase I[44]
Env CD4 binding siteVRC01Phase I[45]
V1V2PGDM1400Phase I[42]
Env V3 glycan sitePGT121Phase I[46]
Env MPER10E8v4Phase I[47]
Env CD4 binding siteN6Phase II[42]

CellularCCR5HGS004Phase I[48]
CCR5PRO140Phase III[49]
CCR5/CCR2CenicrivirocPhase III[50]
CD4TMB-355Phase III[51]
PDL1BMS-936559Phase I[52]