Formulation and Characterization of Solid Dispersion Prepared by Hot Melt Mixing: A Fast Screening Approach for Polymer Selection

Figure 2

Optical microscopic image (40x magnification) using crosspolarized light at 90° for batches described in Table 2. Image of physical mixture of PPP and 20% w/w PEG1000 (a1); physical mixture of PPP, 20% w/w PEG1000, and 20% w/w SUL (a2); hot melt mix of PPP, 20% w/w PEG1000, and 20% w/w SUL (a3); physical mixture of PPP and 20% w/w TEC (b1); physical mixture of PPP, 20% w/w TEC, and 20% w/w SUL (b2); hot melt mix of PPP, 20% TEC, and 20% w/w SUL (b3); physical mixture of HPC and 20% w/w PEG1000 (c1); physical mixture of HPC, 20% w/w PEG1000, and 20% w/w SUL (c2); hot melt mix of HPC, 20% w/w PEG1000, and 20% w/w SUL (c3); physical mixture of HPC and 20% w/w TEC (d1); physical mixture of HPC, 20% w/w TEC, and 20% w/w SUL (d2); hot melt mix of HPC, 20% w/w TEC, and 20% w/w SUL (d3); physical mixture of HPMC and 20% PEG1000 (e1); physical mixture of HPMC, 20% w/w PEG1000 and 20% w/w SUL (e2); hot melt mix of HPMC, 20% w/w PEG1000, and 20% w/w SUL (e3); physical mixture of HPMC and 20% TEC (f1); physical mixture of HPMC, 20% w/w TEC, and 20% SUL (f2); hot melt mix of HPMC, 20% w/w TEC, and 20% SUL (f3).