Genotoxicity Revaluation of Three Commercial Nitroheterocyclic Drugs: Nifurtimox, Benznidazole, and Metronidazole

Table 2

Specific genotoxic activity of NFZ, BNZ, or MTZ on human leukocytes. I: alkaline comet assay; II: comet assay modified with ENDOIII for DNA oxidative damage.

	DNA migration/dose unit (𝜇m/𝜇M)
Drug	I	II
NFX	0.0369 (𝑟^2=0.8043)	0.106 (𝑟^2=0.9732)
BNZ	0.3357 (𝑟^2=0.941)	0.9077 (𝑟^2=0.8351)
MTZ	0.0004 (𝑟^2=0.017)