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Journal of Parasitology Research
Volume 2010, Article ID 610457, 8 pages
http://dx.doi.org/10.1155/2010/610457
Research Article

Lagochilascaris minor: Susceptibility and Resistance to Experimental Infection in Mice Is Independent of H-2a Haplotype and Correlates with the Immune Response in Immunized Animals

1Laboratory of Immunochemistry, Butantan Institute, 05503-900 São Paulo, Brazil
2Laboratory of Immunology, State University of Goiás, 75132-903 Goiânia, Brazil
3Laboratory of Immunology, Catholic University of Goiás, 74605-900 Goiânia, Brazil
4Department of Microbiology, Immunology, Parasitology and Pathology, Institute of Tropical Pathology and Public Health, Federal University of Goiás, 74001-970 Goiânia, Brazil

Received 22 March 2010; Accepted 10 May 2010

Academic Editor: David S. Lindsay

Copyright © 2010 Mônica Spadafora-Ferreira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Recently, we demonstrated that C57BL/6 mice are more susceptible to experimental lagochilascariosis than BALB/c mice. To investigate the pattern of infection and the role of the genetic background on susceptibility to infection, we studied experimental lagochilascariosis in H- identical B10.A and A/J mice. Infected B10.A mice had a lower survival ratio and more severe lesions in the lungs than did A/J mice. Splenocytes of A/J mice immunized with the crude extract of the parasite showed increased proliferation and produced a higher level of interleukin 10 and interferon- in the presence of CE or concanavalin A when compared to B10.A mice. This suggests that resistance of A/J mice may be due to less severe lesions in lungs and other organs and a better immune response to parasite antigens. This paper provides evidence that major histocompatibility complex haplotype does not influence the survival to experimental infection with L. minor.