In Vitro Activity of Geldanamycin Derivatives against Schistosoma japonicum and Brugia malayi

Figure 4

Multiple sequence alignment (Clustal W) of five eukaryotic and one prokaryotic heat shock proteins (Hsp90). Grey-shaded areas indicate residues that comprise the geldanamycin-binding pocket that can be conserved across species [4, 21]. S. cerevesiae : Saccharomyces cerevisiae; E. coli : Escherichia coli; S. japonicum : Schistosoma japonicum; B. malayi : Brugia malayi; C. elegans : Caenorhabditis elegans.