Antiplasmodial Properties and Bioassay-Guided Fractionation of Ethyl Acetate Extracts from Carica papaya Leaves

Table 4

In vitro activity of peaks 1 and 2.

Sample name	D10 IC50  (μg/mL)	DD2 IC50  (μg/mL)	CHO IC50  (μg/mL)	SI-D10 CHO	SI-DD2 CHO	RI
Peak 1	3.58 ± 0.22	4.40 ± 1.10	54.70 ± 2.01	15.27	12.43	1.22
Peak 2	6.88 ± 0.02	6.80 ± 1.21	51.16 ± 5.52	7.43	7.52	0.98

SI = IC₅₀ cytotoxicity/IC₅₀ antiplasmodial activity. RI = IC₅₀ of resistant strain (DD2)/IC₅₀ of sensitive strain (D10).