Inhibition of the Growth of Plasmodium falciparum in Culture by Stearylamine-Phosphatidylcholine Liposomes
Figure 4
Effect of density of cholesterol or DSPE-mPEG-2000 in SPC-SA liposome on plasmocidal activity: cells (1% parasitemia and 2% hematocrit) in the presence of increasing concentrations (1.88 μM–60 μM SA) of SPC-SA liposome containing different density of (a) cholesterol (5, 10, 15, and 20 mol%) (b) DSPE-mPEG-2000 (1, 1.25, and 5 mol %) cultured for 42 h at 37°C. The results are expressed as a percentage of the incorporation of the radioactive precursors as compared to controls incubated in the absence of any liposome.
