Review Article
The Role of Heme and Reactive Oxygen Species in Proliferation and Survival of Trypanosoma cruzi
Table 1
Antioxidant defenses and drug susceptibility of T. cruzi strains.
| Strain | DTU* | Redox state | Drug susceptibility | Reference |
| Y | II | Low concentrations of antioxidant enzymes; lower activity of G6PDH | Resistant | [42, 44] | Tulahuen | VI | High concentrations of antioxidant enzymes; higher activity of G6PDH; lower Thiol contents | Susceptible | [42, 44, 65] | Colombiana | I | High concentrations of antioxidant enzymes; no alteration of TcCPX and TcMPX and FeSOD isoforms | Resistant (natural) | [42, 69ā71] | Cl Brener | VI | No alteration of TcCPX and TcMPX and FeSOD isoforms | Susceptible (in vitro) | [69ā71] |
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*Discrete typing units (DTUs), according to Zingales et al., 2009 [43].
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