Trypanosoma congolense Infections: Induced Nitric Oxide Inhibits Parasite Growth In Vivo
Figure 1
iNOS−/− mice are highly susceptible to infections by T. congolense: enhanced parasitemia and reduced survival time. Groups of 5 to 10 WT or iNOS−/− C56BL/6 mice were infected with low (103) or high () doses of T. congolense TC13 and parasitemia and survival time were determined. The initial parasitemia is about 5-fold higher in iNOS−/− mice infected with 103T. congolense than in infected wild-type (WT) mice (a) and more than100-fold higher in iNOS−/− mice infected with T. congolense than in infected WT mice (b). WT mice infected with either dose survive for more than 30 days (the duration of observation period) (c). iNOS−/− mice infected with 103T. congolense have a mean survival time of days and iNOS−/− mice infected with T. congolense survive for only days (c).
