Research Article

Trypanosoma congolense Infections: Induced Nitric Oxide Inhibits Parasite Growth In Vivo

Figure 2

iNOS−/− mice infected with 103 T. congolense produce no detectable nitric oxide but more IL-10 than infected wild-type (WT) mice. Mice were infected with 103T. congolense. On day 6 postinfection, spleen cells were cultured at an optimal cell density ( /mL) for 48 hours. Cytokines in culture supernatants were measured by ELISA, nitrite by the Griess reaction. * , ** .
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(a) Nitrite
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(b) TNF-α
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(c) IL-12p40
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(d) MCP-1
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(e) IFN-γ
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(f) IL-10