Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice

Figure 4

Extramedullary B lymphopoiesis in spleen during PcAS infection. Spleens cells from noninfected mice and mice infected with PcAS for 10–41 days were stained for surface markers used to define developing B cells. The total B cell precursor population, including pre-pro-B, pro-B, pre-B and immature B, was detected as 7AAD^-Lin^-B220^intAA4.1^hi using FACS. Data are representative of two separate experiments.

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