Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice
Figure 5
Depletion of transitional type 2 B cells in spleen during PcAS infection. (a) Spleens cells from noninfected mice and mice infected with PcAS for 10–41 days were stained for surface markers commonly used to define transitional T2 B cells and analyzed using FACS. Data are represented as mean of three mice per group ± SEM, two independent repeat experiments were performed and statistics are compared to uninfected controls (**) , (***) . (b), (c), and (d) Transitional T2 B cells were detected as (AA4.1+B220+) IgM+CD23+ in uninfected mice and mice on day 10 and 30 pi.
