Acute Disruption of Bone Marrow B Lymphopoiesis and Apoptosis of Transitional and Marginal Zone B Cells in the Spleen following a Blood-Stage Plasmodium chabaudi Infection in Mice
Figure 6
PcAS infection-induced apoptosis of transitional B cells. Spleens cells from uninfected control mice and mice infected with PcAS were stained for surface markers commonly used to define transitional T2 B cells and the amount of active caspase 1, -3, -4, -5, -6, -7, -8 and -9 was measured intracellular by flowcytometry. (a) Percentage of apoptotic cells within T2 transitional B-cell population in uninfected controls versus infected mice on day 11 and 41 pi. Data are represented as mean of three mice per group ± SEM (***) and representative of two separate experiments. (b) Representative histogram of uninfected controls (grey line) versus a day 11 pi (black line).
