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Journal of Parasitology Research
Volume 2011, Article ID 618209, 5 pages
http://dx.doi.org/10.1155/2011/618209
Research Article

Antimalaria Effect of the Ethanolic Stem Bark Extracts of Ficus platyphylla Del

1Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria
2Department of Biochemistry, Kogi State University, P.M.B 1008 Anyigba, Nigeria

Received 14 July 2011; Revised 6 September 2011; Accepted 7 September 2011

Academic Editor: Michael Lanzer

Copyright © 2011 Isma'il Shittu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The antimalarial effect of the ethanolic stem bark extract of Ficus platyphylla Del was evaluated against Plasmodium berghei infection in mice. Nontreated, experimental control mice died of fulminant parasitemia from day 7 to 9 post-infection but mice treated with the extract at 300 mg/kg showed markedly reduced parasitaemia bouts of 43.50% and a mean survival time of 28 days postinfection. The plant extract prevented a drastic reduction in PCV showing its efficacy in ameliorating anaemic conditions in Plasmodium berghei-infected mice. Histological examination of liver tissues of treated and untreated mice further supports the antimalaria potential of this plant. This observation validates the traditional use of this plant for the treatment of malaria.