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Journal of Parasitology Research
Volume 2011, Article ID 965369, 10 pages
Review Article

Malaria Vaccine Development: Are Bacterial Flagellin Fusion Proteins the Bridge between Mouse and Humans?

1Centro de Terapia Celular e Molecular (CTCMol), Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Mirassol 207, São Paulo 04044-010, SP, Brazil
2Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Mirassol, 207, São Paulo 04044-010, SP, Brazil
3Unité de Biologie et Génétique du Paludisme, Institut Pasteur, 75724 Paris Cedex 15, France
4Departamento de Análises Clínicas e Toxicológicas, Faculdade de Ciências Farmacêuticas, Avenida Prof. Lineu Prestes 580, São Paulo 05508-900, SP, Brazil
5Departamento de Genética, Evolução e Bioagentes, Instituto de Biologia, Universidade Estadual de Campinas, Rua Monteiro Lobato, 255, Campinas 13083-970, SP, Brazil
6Departamento de Microbiologia do Instituto de Ciências Biomédicas Universidade de São Paulo, Avenida Prof. Lineu Prestes, 1374, São Paulo 05508-900, SP, Brazil

Received 1 December 2010; Accepted 18 January 2011

Academic Editor: Michael Lanzer

Copyright © 2011 Daniel Y. Bargieri et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [8 citations]

The following is the list of published articles that have cited the current article.

  • Lais Helena Teixeira, Ruth Sonntag Nussenzweig, Victor Nussenzweig, Daniel Youssef Bargieri, Ariane Guglielmi Ariza Camacho, Silvia Beatriz Boscardin, Mauricio Martins Rodrigues, and Irene da Silva Soares, “TLR5-dependent immunogenicity of a recombinant fusion protein containing an immunodominant epitope of malarial circumsporozoite protein and the FliC flagellin of Salmonella Typhimurium,” Memorias Do Instituto Oswaldo Cruz, vol. 106, pp. 167–171, 2011. View at Publisher · View at Google Scholar
  • Raul Terron-Exposito, Benoit Dudognon, Inmaculada Galindo, Jose I. Quetglas, Julio M. Coll, Jose M. Escribano, and Eduardo Gomez-Casado, “Antibodies against Marinobacter algicola and Salmonella typhimurium Flagellins Do Not Cross-Neutralize TLR5 Activation,” Plos One, vol. 7, no. 11, 2012. View at Publisher · View at Google Scholar
  • Jingyi Yang, Maohua Zhong, Yan Zhang, Ejuan Zhang, Ying Sun, Yuan Cao, Yaoming Li, Dihan Zhou, Benxia He, Yaoqing Chen, Yi Yang, Jie Yu, and Huimin Yan, “Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization,” Human Vaccines & Immunotherapeutics, vol. 9, no. 5, pp. 1084–1092, 2013. View at Publisher · View at Google Scholar
  • Guangwen Yin, Mei Qin, Xianyong Liu, Jingxia Suo, Xinming Tang, Geru Tao, Qian Han, Xun Suo, and Wenxue Wu, “An Eimeria vaccine candidate based on Eimeria tenella immune mapped protein 1 and the TLR-5 agonist Salmonella typhimurium FliC flagellin,” Biochemical and Biophysical Research Communications, vol. 440, no. 3, pp. 437–442, 2013. View at Publisher · View at Google Scholar
  • Monica Teixeira Andrade Leal, Mauricio M. Rodrigues, Cibele Aparecida Tararam, Ariane Guglielmi Ariza Camacho, Lais Helena Teixeira, Daniel Youssef Bargieri, and Irene Silva Soares, “Immunogenicity of Recombinant Proteins Consisting of Plasmodium vivax Circumsporozoite Protein Allelic Variant-Derived Epitopes Fused with Salmonella enterica Serovar Typhimurium Flagellin,” Clinical And Vaccine Immunology, vol. 20, no. 9, pp. 1418–1425, 2013. View at Publisher · View at Google Scholar
  • Jana Montero, Eduardo Gómez-Casado, Alicia García Alcázar, José Meseguer, and Victoriano Mulero, “Flagellin from Marinobacter algicola and Vibrio vulnificus activates the innate immune response of gilthead seabream,” Developmental & Comparative Immunology, 2014. View at Publisher · View at Google Scholar
  • Shee Eun Lee, Chung Truong Nguyen, Soo Young Kim, Thinh Nguyen Thi, and Joon Haeng Rhee, “Tetanus toxin fragment C fused to flagellin makes a potent mucosal vaccine,” Clinical and Experimental Vaccine Research, vol. 4, no. 1, pp. 59, 2015. View at Publisher · View at Google Scholar
  • Li Song, Dan Xiong, Xilong Kang, Yang Jiao, Xiaohui Zhou, Kaiyue Wu, Yi Zhou, Xinan Jiao, and Zhiming Pan, “The optimized fusion protein HA1-2-FliC△D2D3 promotes mixed Th1/Th2 immune responses to influenza H7N9 with low induction of systemic proinflammatory cytokines in mice,” Antiviral Research, 2018. View at Publisher · View at Google Scholar