The Role of Vitamin D and Vitamin D Receptor in Immunity to Leishmania major Infection
Figure 1
VDRKO mice develop smaller lesions when infected with L. major. C57BL/6 WT (closed circles) and VDRKO (open circles) mice were infected in the ear with 105 L. major parasites. (a) Cumulative measurement of lesion size (score) was measured over the course of infection. One representative of 5 independent experiments is presented; . (b) Mice were reinfected upon complete resolution of the primary infection (wk 18) and lesions were measured until completely healed. Mean lesion score ± SE is presented; = (11–21 ears). One representative of 2 independent experiments is presented. (c) Parasite burden of infected ears from VDRKO and WT mice was determined at 4, 8, and 12 weeks after infection by performing a limiting dilution assay. Each point indicates the parasite load in a single ear. One representative of 2 independent experiments is presented. .
