Human Schistosome Infection and Allergic Sensitisation

Table 1

Heterogeneity in studies investigating the effect of helminth infection on atopy.


Parasite spp, References	Atopy outcome	Association	Population age

Ascaris lumbrocoides
[37]¹	Wheeze, SPT	Negative	1–4 years
[38]²	IgE, PK	Negative	5–15 years
[39]¹	SPT, airway responsiveness	Positive	8–18 years
[40]²	Allergen-induced Th2 cytokines	None	7–13 years
[41]²	SPT, wheeze	None	9 years mean age
[42]²	SPT	Negative	6–17 years
	Wheeze, eczema, EIB	None
Trichuris trichiura
[38]²	IgE, PK	Negative	5–15 years
[37]¹	Wheeze, SPT	None	1–4 years
[43]^#	SPT	Negative	2–8 years

Hookworm
[37]¹	Wheeze, SPT	None	1–4 years
[42]²	SPT	Negative	6–17 years
	wheeze, eczema, EIB	None
Schistosoma mansoni
[44]¹	SPT, IgE	Negative	years
[45]^#	SPT, asthma symptoms	Negative	15 years mean age
Schistosoma haematobium
[46]¹	SPT	Negative	5–14 years

Cross-sectional ¹ and treatment followup ² studies are reported here.
^#Longitudinal approach but treatment intervention was not the primary objective of the study. SPT: skin prick test; PK: Prausnitz-Kustner passive transfer test, EIB: exercise-induced bronchoconstriction.

Journal of Parasitology Research

Human Schistosome Infection and Allergic Sensitisation

Table 1