Evidence for T Cell Help in the IgG Response against Tandemly Repetitive Trypanosoma cruzi B13 Protein in Chronic Chagas Disease Patients

Figure 5

Direct ELISA for levels of the four subclasses of IgG reactive to recombinant B13 protein in the solid phase in ASY and CCC subjects; HLA+: subjects bearing HLA alleles capable of presenting B13 peptides to T cells (HLA-DQ7, DR1, and DR2); HLA−: subjects bearing other HLA alleles. The horizontal bar indicates median concentration of each subclass in each group: IgG1; 2: IgG2; 3: IgG3; 4: IgG4.