Review Article
Host-Parasite Interaction: Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix
Table 2
Intracellular parasite-derived proteases that degrade human ECM proteins.
| Parasite | Protease | Purified | Gene | Type | ECM substrates |
Localization |
Reference | Collagen | Fibronectin | Laminin | Elastin |
| Trypanosoma cruzi | GP63 or penetrin | Yes | Yes | ND | ND | Yes | Yes | ND | Cell surface | [145, 146] | Cruzipain | Yes | Yes | CP | Yes | ND | ND | ND | Reservosome, cell surface, and secreted | [147ā149] | Cathepsin B-like protease | Yes | Yes | CP | I | ND | ND | ND | Lysosome | [150, 151] | MMP-9 -like proteases (116.1 to 101.3 kDa) | Yes | ND | CP | IV, V, XI, XIV | ND | Yes | Yes | Secreted cell surface | [152, 153] | POP Tc80 | Yes | No | CP | I, IV | Yes | ND | ND | Secreted | [154, 155] | Leishmania | GP63 or leishmanolysin | Yes | Yes | MMP | IV | Yes | No | ND | Cell surface and secreted | [156, 157] |
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