Journal of Parasitology Research / 2012 / Article / Tab 2

Review Article

Host-Parasite Interaction: Parasite-Derived and -Induced Proteases That Degrade Human Extracellular Matrix

Table 2

Intracellular parasite-derived proteases that degrade human ECM proteins.

ParasiteProteasePurifiedGeneTypeECM substrates Localization Reference
CollagenFibronectinLamininElastin

Trypanosoma cruziGP63 or penetrinYesYesNDNDYesYesNDCell surface[145, 146]
CruzipainYesYesCPYesNDNDNDReservosome, cell surface, and secreted[147149]
Cathepsin B-like proteaseYesYesCPINDNDNDLysosome[150, 151]
MMP-9 -like proteases (116.1 to 101.3 kDa)YesNDCPIV, V, XI, XIVNDYesYesSecreted cell surface[152, 153]
POP Tc80YesNoCPI, IVYesNDNDSecreted[154, 155]
LeishmaniaGP63 or leishmanolysinYesYesMMPIVYesNoNDCell surface and secreted[156, 157]

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