Treatment of Plasmodium chabaudi Parasites with Curcumin in Combination with Antimalarial Drugs: Drug Interactions and Implications on the Ubiquitin/Proteasome System
Figure 1
Parasitamia evolution in mice infected with P. chabaudi clone AS-3CQ treated with: chloroquine, curcumin, curcumin/piperine, and curcumin/piperine/chloroquine. Drugs were administered by oral gavage for 4 consecutive days and parasitemia was followed every day following drug treatment for 7 consecutive days. Results represent the mean parasitemia ± S.D. #Significant difference () was found between the curcumin/piperine treatment group versus the curcumin only treatment group. *Significant difference () was found between curcumin/piperine/chloroquine group versus the curcumin only treatment group, curcumin/piperine treatment group, and chloroquine only treatment group (2.5 mg/kg).
