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Journal of Parasitology Research
Volume 2014, Article ID 726328, 11 pages
http://dx.doi.org/10.1155/2014/726328
Review Article

Comparative Analysis of the Omics Technologies Used to Study Antimonial, Amphotericin B, and Pentamidine Resistance in Leishmania

University Avenue, College of Medical, Veterinary and Life Sciences, University of Glasgow, Lanarkshire G12 8Q, UK

Received 20 December 2013; Revised 24 April 2014; Accepted 28 April 2014; Published 12 May 2014

Academic Editor: C. Genchi

Copyright © 2014 Gagandeep Kaur and Bhawana Rajput. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Leishmaniasis is a serious threat in developing countries due to its endemic nature and debilitating symptoms. Extensive research and investigations have been carried out to learn about the mechanism of drug resistance in Leishmania but results obtained in the laboratory are not in agreement with those obtained from the field. Also the lack of knowledge about the mode of action for a number of drugs makes the study of drug resistance more complex. A major concern in recent times has been regarding the role of parasitic virulence in drug resistance for Leishmania. Researchers have employed various techniques to unravel the facts about resistance and virulence in Leishmania. With advent of advanced and more specific means of detection, further hints about probable mechanisms of conferring resistance are expected. This review aims to provide a consolidated picture along with a comparative account of the work done so far to study the mechanism of antimony, amphotericin B, and pentamidine resistance using various techniques.