Table 2: Mouse strains.

StrainCharacteristics

BALB/cReduced susceptibility to Lyme disease related arthritis
Produce IL-4 and develop a Th2 polarized response to B. burgdorferi
Reduction in IL-4 experimentally demonstrated to increase severity of arthritis
Reduced levels of parasitemia in general when infected with B. microti

C3H/xIncreased susceptibility to Lyme disease related arthritis
Produce IFN-γ and develop a Th1 polarized response to B. burgdorferi
Reduction in IFN-γ correlated with reduced arthritis
Supplementation with recombinant IL-4 correlated with reduced arthritis

Mouse substrains HeJ and HeN were used in different studies. The difference between the two substrains is that the HeN strain is endotoxin sensitive (normal LPS response) and the HeJ strain is endotoxin resistant.