In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae)

Figure 3

Sections of liver under high magnification (100x). (a) H. barteri (30 mg/kg), extract treated liver: few hepatocytes contain merosome, and central vein and portal triad appear normal; (b) H. barteri (100 mg/kg), extract treated liver: hepatic necrosis and Kupffer cell hyperplasia; (c) H. barteri (300 mg/kg), extract treated liver: mild haemosiderosis, Kupffer cell hyperplasia, and hepatic necrosis, with traces of periportal mononuclear cells infiltration; (d) liver of negative control mouse: severe hepatic necrosis with Kupffer cells hyperplasia and haemosiderosis; (e) artemether/lumefantrine treated liver: mild hepatic necrosis and traces of periportal mononuclear cells infiltration.

(a) H. barteri 30 mg/kg

(b) H. barteri 100 mg/kg

(c) H. barteri 300 mg/kg

(d) Negative control

(e) Positive control