In Vivo Antiplasmodial, Anti-Inflammatory, and Analgesic Properties, and Safety Profile of Root Extracts of Haematostaphis barteri Hook F. (Anacardiaceae)

Figure 4

Sections of spleen under high magnification (100x). (a) H. barteri (30 mg/kg), extract treated spleen: mild reduction of these pathologies caused by the parasite in the tissues; (b) H. barteri (100 mg/kg), extract treated spleen: mild haemosiderosis and loss of cellular architecture; (c) H. barteri (300 mg/kg), extract treated spleen: mild haemosiderosis and lymphoid hypoplasia; (d) spleen of negative control: severe haemosiderosis; (e) artemether/lumefantrine treated spleen: mild haemosiderosis and severe megakaryoblast hyperplasia.

(a) H. barteri 30 mg/kg

(b) H. barteri 100 mg/kg

(c) H. barteri 300 mg/kg

(d) Negative control, spleen

(e) Positive control