In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice

Table 1

Effect of the solvent fractions of C. papaya fruit rind on parasitemia and survival of P. berghei infected mice on 4-day Peter’s suppression test.

Treatment	Dose in mg/kg/day	% parasitemia	% chemosuppression	Survival date
Petroleum ether fraction	100	40.45 ± 2.1	23.03	8.67 ± 0.52
	200	34.48 ± 4.9	34.38	8.83 ± 0.75
	400	20.08 ± 2.4	61.78	10.33 ± 1.03
Chloroform fraction	100	46.92 ± 4.7	10.72	8.33 ± 0.52
	200	39.83 ± 3.3	24.20	8.67 ± 0.82
	400	32.77 ± 1.61	37.65	9.5 ± 1.05
Methanol fraction	100	48.25 ± 4.38	8.18	7.67 ± 0.52
	200	43.53 ± 3.25	17.16	8.50 ± 0.55
	400	42.88 ± 4.88	18.39	8.17 ± 0.75
Vehicle	1 ml	52.55 ± 5.6	-	7.83 ± 0.75
Chloroquine	25	0	100	30.00 ± 0.00

Data are expressed as mean ± SEM; = 6; to negative control (vehicle; 2% Tween 80), to chloroquine 25 mg/kg, to 100 mg/kg/day of the fraction, to 200 mg/kg/day of the fraction, and to 400 mg/kg/day of the fraction; ; ; .