In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice

Table 2

Effect of the solvent fractions of C. papaya root on parasitemia and survival of infected mice with P. berghei on 4-day Peter’s suppression test.

Treatment	Dose mg/kg/day	% parasitemia	% chemosuppression	Survival date
Petroleum ether fraction	100	41.07 ± 2.55	21.85	8.00 ± 0.63
	200	35.98 ± 3.67	31.53	9.17 ± 0.41
	400	29.55 ± 4.42	43.77	9.83 ± 1.33
Chloroform fraction	100	47.42 ± 1.94	9.77	7.83 ± 0.41
	200	39.28 ± 1.53	25.25	8.83 ± 0.75
	400	27.27 ± 3.36	48.11	10.17 ± 0.75
Methanol fraction	100	47.13 ± 4.39	10.31	7.83 ± 0.75
	200	47.22 ± 4.97	10.15	8.33 ± 1.03
	400	39.08 ± 2.76	25.63	9.00 ± 0.89
Vehicle	1 ml	52.55 ± 5.6	-	7.83 ± 0.75
Chloroquine	25	0.00 ± 0.00	100	30.00 ± 0.00

Data are expressed as mean ± SEM; = 6; to negative control (vehicle; 2% Tween 80), to chloroquine 25 mg/kg, to 100 mg/kg/day of the fraction, to 200 mg/kg/day of the fraction, and to 400 mg/kg/day of the fraction; ; ; .