In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice
Table 3
Effect of the solvent fractions of Carica papaya rind on packed cell volume (PCV) of P. berghei infected mice on 4-day Peter’s suppression test.
Treatment group
Dose mg/kg/day
Packed cell volume
Day 0
Day 4
% change
Pet ether fraction
100
57.7 ± 2.34
56.0 ± 2.83
−3.02
200
58.2 ± 2.04
57.0 ± 1.67
−2.09
400
57.3 ± 2.42
57.2 ± 2.40
−0.29
Chloroform fraction
100
56.3 ± 1.97
53.7 ± 2.94
−5.09
200
56.3 ± 1.50
54.3 ± 2.94
−3.85
400
55.0 ± 1.09
54.7 ± 1.21
−0.62
Methanol fraction
100
57.0 ± 1.09
55.7 ± 2.34
−2.49
200
56.0 ± 1.79
56.0 ± 2.19
−0.04
400
56.3 ± 1.50
56.0 ± 2.83
−0.70
Vehicle
1 ml
56.0 ± 1.79
50.67 ± 3.26
−10.79
Chloroquine
25
57.0 ± 1.55
58.00 ± 2.10
1.69
Data are expressed as mean ± SEM; n = 6; to negative control (vehicle; 2% Tween 80); ;. Day 0 = pretreatment value on day 0. Day 4 = posttreatment value on day four.
