In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice
Table 4
Effect of the solvent fractions of Carica papaya rind on body temperature and weight of P. berghei infected mice on 4-day Peter’s suppression test.
Treatment
Dose mg/kg
Temperature
Weight
Day 0
Day 4
% change
Day 0
Day 4
% change
Pet ether fraction
100
37.1 ± 0.07
36.6 ± 0.33
−1.37
27.3 ± 1.03
26.3 ± 1.97
−4.15
200
37.1 ± 0.13
36.9 ± 0.43
−0.64
22.0 ± 1.90
23.5 ± 1.22
6.41
400
37.1 ± 0.07
36.9 ± 0.25
−0.41
26.0 ± 0.89
25.8 ± 1.17
−0.72
Chloroform fraction
100
37.2 ± 0.14
35.7 ± 0.29
−1.27
24.2 ± 2.14
23.5 ± 2.17
−3.01
200
37.1 ± 0.12
37.0 ± 0.32
−0.36
26.5 ± 2.51
26.7 ± 3.20
0.30
400
37.1 ± 0.08
36.9 ± 0.13
−0.41
24.7 ± 1.97
25.0 ± 1.55
1.23
Methanol fraction
100
37.1 ± 0.13
35.5 ± 0.34
−1.65
25.5 ± 1.05
24.2 ± 1.33
−5.66
200
37.1 ± 0.15
35.7 ± 0.29
−1.09
23.8 ± 0.98
24.3 ± 1.21
1.91
400
37.0 ± 0.08
35.6 ± 0.55
−1.29
24.5 ± 1.22
24.7 ± 1.21
0.62
Vehicle
1 ml
37.1 ± 0.14
34.05 ± 0.78
−5.89
25.33 ± 2.16
22.3 ± 2.25
−13.66
Chloroquine
25
37.1 ± 0.39
37.30 ± 0.32
0.41
33.3 ± 5.05
34.3 ± 5.35
3.16
Data are expressed as mean ± SEM; n = 6; to negative control (vehicle; 2% Tween 80); ;;. Day 0 = pretreatment value on day 0. Day 4 = posttreatment value on day four.
