In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice
Table 5
Effect of the solvent fractions of Carica papaya root on PCV, body temperature, and weight of P. berghei infected mice on 4-day Peter’s suppression test.
Treatment group
Dose mg/kg/day
Packed cell volume
Day 0
Day 4
% change
Petroleum ether fraction
100
55.3 ± 2.94
53.5 ± 1.22
−3.45
200
55.5 ± 1.52
54.3 ± 3.44
−2.34
400
56.3 ± 1.97
55.5 ± 1.52
−1.51
Chloroform fraction
100
55.7 ± 1.50
52.17 ± 2.23
−6.81
200
55.0 ± 1.09
52.7 ± 1.63
−4.47
400
54.7 ± 1.03
53.5 ± 2.17
−2.28
Methanol fraction
100
56.0 ± 1.26
51.7 ± 1.50
−8.41
200
55.0 ± 1.09
49.8 ± 2.23
−10.50
400
55.7 ± 1.50
54 ± 1.79
−3.11
Vehicle
1 ml
56.0 ± 1.79
50.7 ± 3.27
−10.79
Chloroquine
25
56.0 ± 1.55
56.0 ± 2.10
1.69
Data are expressed as mean ± SEM; n = 6; to negative control (vehicle; 2% Tween 80); ;;. Day 0 = pretreatment value on day 0. Day 4 = posttreatment value on day four.
