In Vivo Antimalarial Activity of the Solvent Fractions of Fruit Rind and Root of Carica papaya Linn (Caricaceae) against Plasmodium berghei in Mice

Table 6

Effect of the solvent fractions of C. papaya root on body temperature and body weight of P. berghei infected mice on 4-day Peter’s suppression test.

Treatment group	Dose mg/kg/day	Temperature			Weight
		Day 0	Day 4	% change	Day 0	Day 4	% change
Petroleum ether fraction	100	37.2 ± 0.15	35.9 ± 0.23	−0.68	24.7 ± 3.26	24.2 ± 3.12	−2.20
	200	37.1 ± 0.12	37.0 ± 0.13	−0.18	28.3 ± 2.25	27.5 ± 1.76	−3.04
	400	37.1 ± 0.09	37.0 ± 0.19	−0.22	22.2 ± 1.94	20.8 ± 2.99	−7.36
Chloroform fraction	100	37.1 ± 0.10	35.5 ± 0.38	−1.70	20.2 ± 1.17	19.5 ± 1.05	−3.52
	200	37.2 ± 0.07	36.9 ± 0.10	−0.63	20.5 ± 1.38	19.8 ± 1.72	−3.75
	400	37.1 ± 0.12	36.9 ± 0.16	−0.50	22.7 ± 1.37	21.5 ± 1.52	−5.62
Methanol fraction	100	37.1 ± 0.12	34.5 ± 0.35	−1.60	21.2 ± 1.60	22.5 ± 1.64	1.39
	200	37.1 ± 0.18	34.6 ± 0.27	−1.37	21.0 ± 0.89	18.8 ± 1.94	−12.32
	400	37.1 ± 0.12	35.7 ± 0.29	−1.09	20.3 ± 1.63	19.8 ± 1.72	−2.60
Vehicle	1 ml	37.1 ± 0.13	34.0 ± 0.78	−5.89	25.3 ± 2.16	22.3 ± 2.25	−13.66
Chloroquine	25	37.1 ± 0.39	37.3 ± 0.32	0.41	33.3 ± 5.05	34.3 ± 5.35	3.16

Data are expressed as mean ± SEM; n = 6; to negative control (vehicle; 2% Tween 80); ; . Day 0 = pretreatment value on day 0. Day 4 = posttreatment value on day four.