|
Protein Family | Group | Members | Host | Parasite stage | References |
|
Mucin | TcMUC | TcMUC I | Mammal | Amastigote and bloodstream trypomastigote | [29] |
TcMUC II | Mammal | Amastigote and bloodstream trypomastigote | [30, 31] |
TcMUC III (TSSA) | Mammal | Bloodstream trypomastigote | [30] |
TcSMUG | TcSMUG S | Insect | Epimastigote and metacyclic trypomastigote | [30, 32, 33] |
TcSMUG L | Insect | Epimastigote | [34, 35] |
|
Trans-sialidase | TS I | TCNA | Mammal | Bloodstream trypomastigote | [36–38] |
SAPA | Mammal | Bloodstream trypomastigote | [38] |
TS-epi | Insect | Epimastigote | [39] |
TS II | ASP-1 and ASP-2 | Mammal | Amastigote | [40, 41] |
TSA-1, Tc85, and SA85 | Mammal | Bloodstream trypomastigote | [42–44] |
GP82 | Insect | Metacyclic trypomastigote | [45] |
GP90 | Insect/mammal | Amastigote, bloodstream and metacyclic trypomastigote | [10, 46, 47] |
TS III | CRP, FL160, CEA, and TESA | Mammal | Bloodstream trypomastigote | [48] |
TS IV | TsTc13 | Insect | Metacyclic trypomastigote | [49] |
|
TcGP63 family | TcGP63-I | 61 kDa glycosylated isoform | Insect/Mammal | Epimastigote and amastigote | [50, 51] |
55 kDa nonglycosylated protein | Insect | Metacyclic trypomastigote | [50, 51] |
TcGP63-II | Two transcripts of 2.6 and 2.8 kb | Insect/mammal | Amastigotes, epimastigote, and bloodstream trypomastigote | [50, 52] |
|
Amastin family | δ-Amastins | δ-Amastin and δ-ama40/50 | Mammal | Present in all life cycle, up-regulated in amastigotes stage | [53] |
β-Amastin | β1-Amastin and β2-amastin | Insect/mammal | Present in all life cycle, upregulated in epimastigote stage | [53] |
|
TcTASV family | TcTASV-A | | Mammal | Bloodstream trypomastigote | [54] |
TcTASV-B | | Mammal | Bloodstream trypomastigote | [54] |
TcTASV-C | | Mammal | Bloodstream trypomastigote | [55] |
|
MASP family | | | Insect/mammal | Amastigote, epimastigote, bloodstream and metacyclic trypomastigote | |
|
Cruzipain family | N-cruzipain | | Insect | Epimastigote | [56, 57] |
R-cruzipain 1 (cruzain) | | Insect/mammal | Epimastigote, bloodstream trypomastigote and amastigote | [58, 59] |
R-cruzipain 2 | | Mammal | Bloodstream trypomastigote and amastigote | [56] |
|