Low IL-6, IL-10, and TNF-α and High IL-13 Cytokine Levels Are Associated with Severe Hepatic Fibrosis in Schistosoma mansoni Chronically Exposed Individuals
Table 2
Median (interquartile range) cytokine levels (pg/ml) in the nonfibrotic and fibrotic groups.
Cytokine
No fibrosis
Fibrosis
value
IL-2
0.93 (0, 2.28)
0.78 (0, 1.92)
0.365
IL-4
0.20 (0, 1.11)
0 (0.0, 0.88)
0.264
IL-6
11208 (7571, 14714)
8058 (4146, 11030)
<0.001
IL-10
139.6 (76.80, 239.20)
77.7 (32.0, 128.70)
<0.001
IL-13
0.57 (0.17, 2.92)
1.45 (0.26, 4.67)
<0.001
IL-17A
4.59 (1.7, 10.0)
6.64 (3.18, 12.63)
0.05
IFN-γ
1.35 (0.17, 2.92)
0.78 (0.23, 2.17)
0.23
TNF-α
722.2 (404.8, 1174.6)
451.0 (218.4, 828.2)
<0.001
The Mann–Whitney test was used to compare differences in median cytokine levels in individuals without fibrosis and those with fibrosis.
