Journal of Parasitology Research / 2019 / Article / Tab 4

Research Article

Antimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants

Table 4

Cytotoxicity of crude extracts in LLC-MK2 cells and selectivity index (SI) values in the three tested Plasmodium falciparum strains.

ExtractCC50 on LLC-MK2
(μg/mL)
Selectivity Index (SI)
FCBW2CAM06

Paspalum scrobiculatum157.1 ± 0.986.5423.779.63
Bidens pilosa 102.2 ± 0.864.3422.174.76
Acridocarpus alternifolius> 1,00023.7448.2327.02
Clappertonia ficifolia273.5 ± 2.0261.7434.4541.69
Mitragyna ciliata262.7 ± 1.6611.6114.095.40
Parinari congensis150.6 ± 1.2712.052.923.34
Monanthotaxis caffra88.6 ± 0.4615.124.684.78
Datura stramonium> 1,000128.6514.6337.09
Faurea speciosa154.9 ± 7.8910.4516.6422.29
Syzygium guineense77.9 ± 0.715.2116.8614.06
Croton penduliflorus Hutch272.0 ± 2.0250.6519.3918.55
Gleevec (Imatinib)18.50 ± 1.21

CC50, = cytotoxic concentration 50%.
Mean and standard deviation values of CC50 were generated from three replicate experiments.
CC50 < 5: highly toxic; 5 < CC50 <10: cytotoxic; 10 < CC50 < 30: moderately to weakly cytotoxic; and CC50 > 30: noncytotoxic [17].

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