Therapeutic Efficacy of Artemether-Lumefantrine (Coartem®) for the Treatment of Uncomplicated Falciparum Malaria in Africa: A Systematic Review

Table 1

Characteristic of the included studies, 2015-2019.

Author and year of publication	Country	Study design	Follow-up (in days)	Study subjects
				Sample size	Male %	Included age groups
Mwaiswel, 2016	Tanzania	A randomized, single-blind clinical trial	28	110	50	>/=1 year
Koita, 2017	Mali	A randomized, clinical trial	42	33	100	≥18 years
Yeka, 2016	Uganda	A randomized trial	28	302	54	6 to 59 months
Ndounga, 2015	Congo	A randomized study	28	133	57.1	<10 years
Ebstie, 2015	Ethiopia	Observational cohort study	28	130	60	>5 years
Sirima, 2016	Sub-Saharan Africa	A randomized, multicentre, trial	63	407	49	<5 years
Chandra, 2015	Multi-center	A randomized, open-label study	42	131	50.4	6 to 59 months
Kilonzi, 2019	Tanzania	Prospective study	28	100	56	6 to 59 months
Sondo, 2015	Burkina Faso	A randomized open-label trial	28	340	53.8	All age
Salvador, 2017	Mozambique	Prospective one-arm study	28	349	52.3	Children
Davlantes, 2018	Angola	An in vivo assessment	28	185	54	Children
Kakolwa, 2018	Tanzania	Open-label single arm study	28	182	50	>/=6 months
Plucinski, 2015	Angola	Open-label, nonrandomized study	28	157	nr	6 months to 9 years
Denoeud,2016	Mali and Niger	Open comparative intervention study	28	397	47.8	< 5 years
Mekonnen, 2015	Ethiopia	Open-label single arm study	28	93	59.8	>6 months
Plucinski, 2017	Angola	Open-label single arm study	28	178	60	6 months to 12 years
Smith, 2018	Sierra- Leone	One-arm prospective study	28	64	65.6	6 to 59 months
Ebenebe, 2018	Nigeria	Open-label trial	28	324	53.7	<5 years
Warsame, 2017	Somalia	One-arm prospective study	28	284	66.9	6 months to 60 years
Grandesso,2018	Niger	One-arm prospective study	42	218	50	6 to 59 months
Adeel, 2016	Sudan	One-arm prospective study	28	595	48	All age group
Niaré, 2016	Mali	Randomized open-label assay	28	237	58.7	>/= 6 months
Paczkowski, 2016	Malawi,	Randomized efficacy trial	28	338	52.1	6 to 59 months
De Wit, 2016	D.R. Congo	Open-randomized trial	42	144	79	6 to 59 months
Dambe, 2015	Malawi	One-arm prospective study	28	322	49.6	6 to 59 months
Wudneh, 2016	Ethiopia	Open-label trial	28	91	82.4	>/=6 months
Roth, 2018	Kenya	A randomized controlled trial	28	96	50	6 months to ≤12 years
Nji, 2015	Cameroonian	Randomized trial	42	142	47.2	6 months to 10 years
Ukah, 2015	Nigeria	Double-blind randomized trial	28	75	0	Pregnant women
Dama, 2018	Mali	Randomized trial	42	158	53	All age group
Sowunmi, 2017	Nigeria	Randomized trial	42	517	57	</=15 years
Sowunmi, 2016	Nigeria	Randomized trial	28	517	55.1	</=15 years
Nega, 2016	Ethiopia	Open-label single-arm study	28	91	75.8	All age group
Teklemariam, 2017	Ethiopia	Open-label single-arm study	28	92	61.9	All age group
Ogouyèm2016	Benin	Open-label, single-arm trial	42	123	63	6 months to 5 years
Getnet, 2015	Ethiopia	One-arm prospective study	28	80	57.5	All age groups
Ayogu, 2015	Nigeria	A prospective study	28	154	22.7	All age group
Abuaku, 2016	Ghana	One-arm prospective study	28	170	55	6 months to 9 years
Dorkenoo, 2016	Togo	One-arm prospective study	28	261	54.8	6 to 59 months

nr: not reported, yrs: years.