Therapeutic Efficacy of Artemether-Lumefantrine (Coartem®) for the Treatment of Uncomplicated Falciparum Malaria in Africa: A Systematic Review

Table 4

Uncomplicated falciparum malaria treatment outcome including parasite and fever clearance rate, 2015-2019.

Author, year	% parasite clearance at day 3	% fever clearance at day 3	% treatment failure			% reinfection	% recrudescence	Most common AE
			ETF	LCF	LPF
Mwaiswel, 2016	100	100	0	5.8	1.9	4.8	1.0	—
Koita, 2017	100	100	—			6	—	—
Yeka, 2016	100	88.6	0	21.1	22.9	44.6	2.5	Cough
Ndounga, 2015	—	97	0	4.2	5.9	6	3	Fatigue
Ebstie, 2015	96.1	87.9	0	0	1.6	—	—	Weakness
Sirima, 2016	94.6	94	0	25.6	52.6	—	—	Anemia
Chandra, 2015	>90		—	—	—	—	—	Abdominal pain
Kilonzi, 2019	100	100	0	1.3	22.7		—	—
Sondo, 2015	—	—	0.6	6.6	15	0.3	0.25	Cough
Salvador, 2017	99.1	—	0	1.2	0			—
Davlantes, 2018	100	—	0	8.6	—	3.8	1.5	—
Kakolwa, 2018	—	—	0	0	4.3		—	Cough
Plucinski, 2015	98.8	—	0.6	14.6	—	8.9	5.7	—
Denoeud,2016	—	—	0			15.2	1	GIT disorders
Mekonnen, 2015	100	100	0	1.1	4.5	2.2	2.2	—
Plucinski, 2017	100	—	1.7	15.7	—	3.4	0.6	—
Smith, 2018	100	—	—	0	8.9	—	—	—
Ebenebe, 2018	97.9	—	9			—	2.1	Cough
Warsame, 2017	100	—	0	0.7	0.3	—	—	Fever
Grandesso,2018	100	—	0	0.8	0.8	0.20	2.6	Fever
Adeel, 2016	100	—	1	0	0	—	—	—
Niaré, 2016	—	—	0	—	12.34	12.6	—	—
Paczkowski, 2016	99.7	—	0	23.8		23.1	0.7	—
De Wit, 2016	95.6	—	0	3.3	4.9	—	5.3	Asthenia
Dambe, 2015	99.1	—	1.6	4.1	0.9	—	0	URTI and pneumonia
Wudneh, 2016	100	100	0	0	1.2	0	1.2	Headache
Roth, 2018	97.5	100	0	0	3.6	0	1.2
Nji, 2015	90	>90	0	0.8	2.4	—	—	Vomiting
Ukah, 2015	93.0	—	0	1.3	4	—	—	—
Dama, 2018	> 90.5	100	0	0	1.9	—	—	—
Sowunmi, 2017	100	100	0	6.7		—	—	—
Sowunmi, 2016	99.4	100	0	6.7		—	6.1	Cough
Nega, 2016	100	96.6	0	1.2	1.2	1.2	1.2	—
Teklemariam, 2017	100	100	0	1.3	0	—	—	Headache
Ogouyèm2016		100	0	8.9	4.1			—
Getnet, 2015	94.9	96.3	2.5	2.5	3.8	2.5	0	Headache
Ayogu, 2015	80.4	100	0	3.4	25.4	—	—	—
Abuaku, 2016	100	100	0	4.7	14.1	—	—	Diarrhea
Dorkenoo, 2016	100	—	0	0	1.5	—	—	—

ACPR: adequate clinical and parasitological response; PCR: polymerase chain reaction; ETF: early treatment failure; LCF: late clinical failure; LPF: late parasitological failure; AE: most frequent adverse event; URTI: upper respiratory tract infection.