The Effectiveness of Varying Combination Ratios of A. cordifolia and M. indica against Field and Laboratory Strains of P. falciparum In Vitro
Table 1
The drug combination of A. cordifolia with M. indica against NF54, FA08, and CamWT_C580Y Plasmodium parasite strains.
Drugs
HE ratio
IC50
CI
Interaction
Correlation coefficient ()
()
NF54
Ac
N/A
2.71
N/A
N/A
0.988
Mi
N/A
18.11
N/A
N/A
0.988
Ac + Mi
02 : 01
4.98
0.75
Syn
0.999
Ac + Mi
01 : 02
8.58
0.58
Syn
1
Ac + Mi
01 : 01
6.43
0.78
Syn
1
Ac + Mi
04 : 01
4.52
0.72
Syn
1
Ac + Mi
01 : 04
10.04
0.66
Syn
1
Ac + Mi
01 : 05
10.54
0.61
Syn
1
Ac + Mi
10 : 01
13.60
2.56
Anta
0.995
Ac + Mi
20 : 01
16.40
2.83
Anta
1
FA08
Ac
N/A
3.55
N/A
N/A
0.888
Mi
N/A
10.23
N/A
N/A
0.934
Ac + Mi
02 : 01
770.26
3.3488
Anta
0.134
Ac + Mi
01 : 02
10.92
3.03
Anta
0.786
Ac + Mi
01 : 01
11.99
2.41
Anta
0.89
Ac + Mi
04 : 01
20.73
15.34
Anta
1
Ac + Mi
01 : 04
10.74
0.90
Syn
1
Ac + Mi
10 : 01
19.81
2.65
Anta
1
Ac + Mi
20 : 01
22.33
2.29
Anta
1
CamWT
Ac
N/A
7.80
N/A
N/A
0.933
Mi
N/A
20.08
N/A
N/A
0.938
Ac + Mi
02 : 01
13.47
0.30
Syn
1
Ac + Mi
01 : 02
11.38
0.19
Syn
1
Ac + Mi
01 : 01
12.93
0.32
Syn
1
Ac + Mi
04 : 01
17.42
0.79
Syn
1
Ac + Mi
01 : 04
10.18
0.17
Syn
1
Ac + Mi
01 : 05
13.72
0.55
Syn
1
Ac + Mi
10 : 01
14.57
1.05
Add
0.976
Ac + Mi
20 : 01
4.91
6.75
Anta
1
IC50 (μg/mL) signifies potency, and represents linear correlation coefficient. , <1, and >1 depict additive effect, synergism, and antagonism, respectively. The dose and inhibition effect data were obtained from the SYBR Green I asexual Parasite drug assay in-vitro (). The data in this table was generated from the Compusyn software report. Ac: A. cordifolia; Mi: M. indica extract; CamWT: CamWT_580Y; Syn: synergy; Add: additive; anta: antagonistic.
