Journal of Probability and Statistics / 2012 / Article / Fig 2

Research Article

The Transmission Disequilibrium/Heterogeneity Test with Parental-Genotype Reconstruction for Refined Genetic Mapping of Complex Diseases

Figure 2

Power of RC-TDH (solid) and RC-TDT (dashed) in Table 5 (scenario 5). This figure is based on scenario 5: , , , and . The type I error rate is 0.001 based on 500 independent replicates of 200 nuclear families, 50% of which without parental information. Every family contains 3 sibs and at least one is affected. is the measurement for linkage disequilibrium as defined by in Section 4.1. When  = 0, there is no linkage disequilibrium.

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