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Journal of Probability and Statistics
Volume 2012, Article ID 317634, 18 pages
http://dx.doi.org/10.1155/2012/317634
Research Article

Escalation with Overdose Control Using Ordinal Toxicity Grades for Cancer Phase I Clinical Trials

Samuel Oschin Comprehensive Cancer Institute, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA

Received 29 June 2012; Accepted 10 September 2012

Academic Editor: Zhengjia Chen

Copyright © 2012 Mourad Tighiouart et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [6 citations]

The following is the list of published articles that have cited the current article.

  • Mourad Tighiouart, Steven Piantadosi, and André Rogatko, “Dose finding with drug combinations in cancer phase I clinical trials using conditional escalation with overdose control,” Statistics in Medicine, 2014. View at Publisher · View at Google Scholar
  • Mourad Tighiouart, Yuan Liu, and André Rogatko, “Escalation with overdose control using time to toxicity for cancer phase I clinical trials,” PLoS ONE, vol. 9, no. 3, 2014. View at Publisher · View at Google Scholar
  • Oleksandr Sverdlov, Weng Kee Wong, and Yevgen Ryeznik, “Adaptive clinical trial designs for phase I cancer studies,” Statistics Surveys, vol. 8, pp. 2–43, 2014. View at Publisher · View at Google Scholar
  • Thomas M. Braun, “The current design of oncology phase I clinical trials: Progressing from algorithms to statistical models,” Chinese Clinical Oncology, vol. 3, no. 1, 2014. View at Publisher · View at Google Scholar
  • Andre Rogatko, Galen Cook-Wiens, Mourad Tighiouart, and Steven Piantadosi, “Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding,” Entropy, vol. 17, no. 8, pp. 5288–5303, 2015. View at Publisher · View at Google Scholar
  • Suyu Liu, and Valen E. Johnson, “A robust Bayesian dose-finding design for phase I/II clinical trials,” Biostatistics, vol. 17, no. 2, pp. 249–263, 2015. View at Publisher · View at Google Scholar