Escalation with Overdose Control Using Ordinal Toxicity Grades for Cancer Phase I Clinical Trials

Figure 2

Dose-toxicity relationship for the nine scenarios considered in the design operations characteristics. The solid curves correspond to 𝑃(𝑌=2∣𝑥)=𝑃(𝐷𝐿𝑇∣𝑥) and the dashed curves in bold correspond to 𝑃(𝑌>1∣𝑥). The horizontal dashed lines represent the target probability of DLT 𝜃=0.33 and the vertical lines correspond to the true values of the MTD 𝛾.

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