Escalation with Overdose Control Using Ordinal Toxicity Grades for Cancer Phase I Clinical Trials

Table 1

Percent of trials with estimated MTD within 5% of the dose range and 10% of the dose range of the true MTD 𝛾 and percent of trials for which the rate of DLT exceeds 40% for EWOC and EWOC-POM under the nine scenarios.

Scenarios	Percent of trial with estimated MTD				Percent of Trial
	Within 0.05 of γ		Within 0.10 of γ		with rate of DLT >0.4
	EWOC	EWOC-POM	EWOC	EWOC-POM	EWOC	EWOC-POM
γ = 0.1, 𝜌1 = 0.2	98.3	98.4	100	100	7.5	6.6
γ= 0.1, 𝜌1 = 0.5	98.3	97.5	100	100	7.5	3.0
γ= 0.1, 𝜌1 = 0.8	98.3	96.4	100	100	7.5	2.9
γ= 0.5, 𝜌1 = 0.2	39.6	40.5	70.3	71.3	0.2	0.0
γ= 0.5, 𝜌1 = 0.5	39.6	35.6	70.3	63.2	0.2	0.0
γ= 0.5, 𝜌1 = 0.8	39.6	31.0	70.3	59.4	0.2	0.0
γ= 0.7, 𝜌1 = 0.2	24.3	27.6	49.1	53.3	0.0	0.0
γ= 0.7, 𝜌1 = 0.5	24.3	23.2	49.1	45.7	0.0	0.0
γ= 0.7, 𝜌1 = 0.8	24.3	20.1	49.1	37.1	0.0	0.0