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Journal of Probability and Statistics
Volume 2012 (2012), Article ID 375935, 19 pages
Research Article

Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease

1Department of Biostatistics, Mailman School of Public Health, Columbia University, 722 West 168th Street, New York, NY 10032, USA
2Department of Statistics, Texas A&M University, College Station, TX 77843, USA
3Departments of Neurology and Psychiatry and Sergievsky Center and the Taub Institute, Columbia University Medical Center, New York, NY 10032, USA
4Department of Psychiatry and Biostatistics (Secondary), University of Iowa, Iowa City, IA 52242, USA

Received 15 December 2011; Accepted 22 February 2012

Academic Editor: Yongzhao Shao

Copyright © 2012 Tianle Chen et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [5 citations]

The following is the list of published articles that have cited the current article.

  • Yanyuan Ma, and Yuanjia Wang, “Nonparametric modeling and analysis of association between Huntington's disease onset and CAG repeats,” Statistics in Medicine, 2013. View at Publisher · View at Google Scholar
  • Mahdi Teimouri, Saralees Nadarajah, and Shou Hsing Shih, “EM algorithms for beta kernel distributions,” Journal of Statistical Computation and Simulation, vol. 84, no. 2, pp. 451–467, 2014. View at Publisher · View at Google Scholar
  • Tianle Chen, Yanyuan Ma, and Yuanjia Wang, “Predicting cumulative risk of disease onset by redistributing weights,” Statistics in Medicine, vol. 34, no. 16, pp. 2427–2443, 2015. View at Publisher · View at Google Scholar
  • Martha A. Nance, “Genetic counseling and testing for Huntington's disease: A historical review,” American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2016. View at Publisher · View at Google Scholar
  • Marcela Gargiulo, Sophie Tezenas du Montcel, Marie France Jutras, Ariane Herson, Cecile Cazeneuve, and Alexandra Durr, “A liminal stage after predictive testing for Huntington disease,” Journal of Medical Genetics, pp. jmedgenet-2016-104199, 2017. View at Publisher · View at Google Scholar