Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease

Table 5

Mean and standard deviation of the AAO estimated from the model (2.1) for four analyses.

	Langbehn		COHORT data
	data		Probands diagnosis^∗		Probands symptom^∗∗		Combined symptom^†
CAG	Mean	SD	Mean	SD	Mean	SD	Mean	SD
41	57.06	10.50	59.84	8.78	57.74	9.13	59.33	11.68
43	48.06	8.62	51.17	7.31	49.32	7.90	50.63	9.60
46	38.66	7.08	41.29	5.97	39.66	6.57	41.20	7.59
48	34.32	6.57	36.31	5.47	34.75	5.95	36.69	6.79
50	31.08	6.28	32.32	5.16	30.80	5.50	33.21	6.28

^∗∶ using proband age-at-diagnosis data;
∗∗: using proband age-at-first-symptom data;
†: using proband and relative combined age-at-first-symptom data.