Review Article
Analysis of Longitudinal and Survival Data: Joint Modeling, Inference Methods, and Issues
Table 2
Comparison of the two-stage Method and the joint likelihood method via a simulation study.
| Method | Parameter | | | | | | | True value | 0.6 |
−0.2
| 1.3 | 0.6 | 0.5 | 0.3 |
| Two-stage | Est | 0.183 |
−0.183
| 1.303 | 0.598 | 0.501 | 0.353 | ESE | 0.216 |
0.111
| 0.164 | 0.025 | 0.114 | 0.209 | ASE | 0.201 |
0.111
| 0.164 | — | — | — | BSE | 0.250 | — | — | — | — | — | Bias |
−0.417
| 0.017 | 0.003 |
−0.002
|
−0.001
| 0.053 | MSE | 0.221 | 0.013 | 0.027 | 0.0007 | 0.013 | 0.046 | CR | 42.8 | 95.6 | 94.4 | — | — | — |
| Joint model | Est | 0.6004 |
−0.175
| 1.296 | 0.598 | 0.492 | 0.321 | ESE | 0.256 | 0.103 | 0.161 | 0.020 | 0.092 | 0.156 | ASE | 0.249 | 0.099 | 0.163 | — | — | — | Bias | 0.0004 | 0.025 |
−0.004
|
−0.002
|
−0.008
| 0.021 | MSE | 0.066 | 0.011 | 0.026 | 0.0004 | 0.008 | 0.025 | CR | 95.6 | 95.8 | 95.2 | — | — | — |
|
|