Parameter Estimation of Population Pharmacokinetic Models with Stochastic Differential Equations: Implementation of an Estimation Algorithm

Table 1

Mean estimates and 95% credibility interval in brackets obtained from the SDE mixed-effects models and ODE models on 500 simulated datasets.

Parameter	True value	SDE estimation; (confidence interval)	ODE estimation; (confidence interval)
	0.2	0.1999; (0.1999, 0.2006)	0.0984; (−0.6448, 0.8416)
	0.5	0.4755; (0.47503, 0.5213)	0.5339; (0.4089, 0.6589)
	0.25	0.2501; (0.2499, 0.2501)	0.1815; (−0.0303, 0.3932)
	0.01	0.0173; (0.0063, 0.0467)	—
	0.1	0.1482; (0.0176, 0.1812)	—
	0.02	0.0174; (0.0035, 0.0402)	—
	0.2	0.1488; (0.1343, 0.2441)	—
	0.1	0.0793; (0.0402, 0.1091)	—
	0.1	0.1087; (0.0767, 0.1515)	—