Berberine Reshapes the Balance of the Local Renin-Angiotensin System by Modulating Autophagy under Metabolic Stress in Pancreatic Islets

Figure 3

Berberine ameliorated metabolic parameters. (a) Effect of berberine on body weight. (b) Effect of berberine on food intake. (c) Intraperitoneal glucose and insulin tolerance tests (IPGTTs). Serum glucose levels were determined in overnight-fasted or 6-hour-fasted mice of each genotype (4 and 8 weeks). (d) Insulin levels from vehicle-treated mice and BBR-treated mice. Serum insulin levels were determined in overnight-fasted mice of each genotype by ELISA (8 weeks). (e) The homeostatic model assessment of insulin resistance (HOMA-IR) index. . (f) Representative images of immunofluorescence staining for insulin and glucagon (×400). WT (): wild-type C57BL/6 J mice; ob/ob (): ob/ob mice; Ob-BBR (): berberine-treated ob/ob mice. Data were expressed as the , , vs. ob/ob group; ^## vs. WT group.

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