Aldosterone Induces the Proliferation of Renal Tubular Epithelial Cells In Vivo but Not In Vitro

Figure 1

Eplerenone attenuates renal fibrosis in aldosterone-infused mice. Staining (Sirius Red, Masson) was used to evaluate the degree of renal fibrosis. In the UA group, collagen fibers were deposited around blood vessels. . Values are the , vs. sham, vs. sham, vs. sham; ^# vs. UA, ^## vs. UA, ^### vs. UA. UN group: unilateral nephrectomy for 6 weeks; UA group: unilateral nephrectomy + aldosterone perfusion. 5 days after surgery, an osmotic minipump was implanted (s.c.) to infuse aldosterone (0.75 μg·h⁻¹) for 6 weeks. UAE group: UA mice were given eplerenone (100 mg·kg⁻¹d⁻¹).