Research Article
Aldosterone Induces the Proliferation of Renal Tubular Epithelial Cells In Vivo but Not In Vitro
Figure 5
Effect of aldosterone on the cycle in HK2 cells (a) and mDCT cells (b). Effects of aldosterone (0, 10−9, 10−8, 10−7, and 10−6 mol/L) on the number and DNA content of HK2 cells for 3 (a1), 6 (a2), 12 (a3), 24 (a4), 36 (a5), or 48 (a6) hours. Effects of aldosterone on the number and DNA content of mDCT cells treated with aldosterone (0, 10−9, 10−8, 10−7, and 10−6 mol/L) for 3 (b1), 6 (b2), 12 (b3), 24 (b4), 36 (b5), or 48 (b6) hours. Percentage of cells in the G2/M phase cells is presented as a bar graph; each bar represents the (). (c) Proliferation cycle of HK2 cells. (d) mDCT cells. mDCT: mouse distal convoluted tubule epithelial; HK2: human kidney proximal tubular epithelial.
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