Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam

Figure 2

Effect of glucocorticoid (GR) and mineralocorticoid (MR) receptor blockade on renal lipid content in Wistar dams exposed to combined oral contraceptives (COC). GR and MR blockades ameliorated renal TG/HDL-C (triglyceride/high-density lipoprotein) ratio (a), MR blockade attenuated TC/HDL-C (total cholesterol/high-density lipoprotein) ratio (b), and GR and MR blockades ameliorated renal FFA (free fatty acid) (c) in COC-treated Wistar rat dams. Post gestational COC exposure, GR and MR blockade were carried out for eight weeks after the 3-week postgestational period. Data were presented as , and was taken as statistically significant. vs. DAM; ^# vs. DAM+COC. Data were analyzed by one-way ANOVA and Bonferroni’s post hoc analysis. DAM: control; DAM+COC: combined oral contraceptive exposure; DAM+COC+GR: COC exposure with glucocorticoid receptor blockade; DAM+COC+MR: COC exposure with mineralocorticoid receptor blockade.

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