Suppression of Adenosine Deaminase and Xanthine Oxidase Activities by Mineralocorticoid and Glucocorticoid Receptor Blockades Restores Renal Antioxidative Barrier in Oral Contraceptive-Treated Dam

Figure 5

Effect of glucocorticoid (GR) and mineralocorticoid (MR) receptor blockades on renal lactate and lactate dehydrogenase in Wistar dams exposed to combined oral contraceptives (COC). GR but not MR blockade reduced renal lactate (a), and MR but not GR blockade reduced renal LDH (lactate dehydrogenase) (b) in COC-treated Wistar rat dams. Post gestational COC exposure, GR and MR blockades were carried out for eight weeks after the 3-week postgestational period. Data were presented as , and was taken as statistically significant. vs. DAM; ^# vs. DAM+COC. Data were analyzed by one-way ANOVA and Bonferroni’s post hoc analysis. DAM: control; DAM+COC: combined oral contraceptive exposure; DAM+COC+GR: COC exposure with glucocorticoid receptor blockade; DAM+COC+MR: COC exposure with mineralocorticoid receptor blockade.

(a)

(b)